KIN330 Lecture Notes - Lecture 3: Dementia, Syphilis

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Syphilis: primary stage, cause: bacterium transmitted via sexual contact, 4 6 weeks to heal, a syphilis sore on the skin (chancres, secondary stage, highly infectious, latent stage (untreated, 1 10 years, relatively asymptomatic, infection is underground , late stage (untreated, 2 50 years, damage to major organ systems, difficulty coordinating muscle movements, dementia, may cause death, treatment, penicillin (if treated early enough, cured with one dose) Tuskegee study: n = 600 african americans, 399 with syphilis, 201 without, duration of experiment: 1932 to 1972, most participants in syphilis group were left untreated and misinformed about their medical status, so researchers can examine natural course of syphilis (untreated) Core principles: respect for persons ( autonomy , self determination: capacity of individuals to make decisions affecting their lives and act on those decisions, internally consistent with intention, protected from external control, concern for welfare ( beneficence , obligation to attend to the well being of subject.

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