BIOL 4370 Lecture Notes - Voltage Clamp, Patch Clamp, Pipette
16 Mar 2014
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Nov. 21st: eeg: used noninvasively in human. Electrodes are placed on skull and voltage difference between electrodes are recorded. Afferent axons releases glutamate and causes na to rush into cell. Na rushing into cell causing lack of sodium in fluid (negative voltage) Irregular activity in afferent axons doesn"t show anything in eeg, but if afferent axons are synchronized then you can see negative blips in eeg (eeg adds up sum of all afferent axons) Half of dolphins wave is on during sleep (greater eeg signals: extra cellular recordings: allow us to record form a single neuron. Records voltage changes (as a result of aps)at membrane of neuron. Microelectrode (stretched tube with fine point) has saline solution inside it which conducts electricity (voltage in cell generates current in microelectrode) Needs amplifier for voltage change to be observable. Microelectrode records voltage changes outside of cell in csf. Humans can differentiate between words based on length of sound.
