Biology 2382B Lecture Notes - Lecture 6: Transferrin Receptor, Ldl Receptor, Hypercholesterolemia
23 Mar 2014
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Document Summary
A method of selective internalization of specific extracellular molecules (ligands) Ldl, transferrin, hormones, certain glycoproteins, etc. cell membrane receptors; it wraps around outside of ldl particle as a band of protein. No ldl receptor, receptor binds ldl poorly, receptor can t internalize ldl. Mediates turnover of long-lived proteins and excess or aberrant organelles. Cup-shaped double membrane forms around portions of cytosol or organelle (mitochondrion) Atg8 protein steals membrane to form autophagic vesicle. Fusion of outermembrane with membrane of a lysosome releases a single layer vesicle and its contents to be degraded. Ferrotransferrin; transferrin dimer carrying 2 fe3+, binds to transferrin receptor (neutral ph) Fuses with late endosome; low ph causes release of fe3+, but ligand remains bound to receptor now called.
