LMP299Y1 Lecture Notes - Lecture 9: Shortness Of Breath, Pulse Pressure, Radionuclide
7 Apr 2014
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Lecture 9 : thyroid diseases. Reverse t3 (rt3) is an inactive form metabolized from t4. T3 binds to receptor and triggers target cell to promote metabolism. Local thyroid status can be modulated by the relative production of t3 and rt3. Thyroid hormones are essential for the normal maturation and metabolism of all tissues in the body. Changes of tbh binding affects thyroid function tests. Can decrease tbg synthesis in the liver (by increasing liver production) Less binding protein (less t3 and t4 bound to the binding. When there is an increase protein = bound form is decreased) level of tbg in the circulation. But because the normal patient with functioning thyroid can. Total hormone (because bound fraction has been decreased) a normal thyroid function, they. Inhibit binding of thyroid hormones to tbg decrease binding affinity. Same effect as decrease in binding = less bound form. Free hormone is more important to biological effect of thyroid gland and thyroid hormone status.
