KINS 1224 Lecture Notes - Inotrope, Medulla Oblongata, Cardiac Output
Document Summary
Introduction: circulatory system, heart, blood vessels, blood, transportation, protection, regulation, cardiovascular system, heart and blood vessels, transportation of blood. Interdigitating folds: mechanical junction, desmosomes, fascia adherens, electrical junction, gap function ii. Functional syncytium : cardiac muscle metabolism, aerobic metabolism, vulnerable to oxygen deficiency, not prone to fatigue, adaptable to organic fuels, at rest, 60% fa"s. 35% glucose, 5% other fuels: can change to metabolic pathways, even use lactic acid, cardiac conduction system, autorhythmic cells, modified cardiac muscle cells, 1% of total, function independently i. All or none : applies to whole organ, atria and ventricles not electrically connected, functional syncytium, purkinje fibers, fastest, supply papillary muscles, electrical behavior of myocardium a. Individual contractile muscle: resting membrane potential is -90mv, action potential of ventricular myocyte, ventricular myocyte action potential, rapid depolarization, na+ inflow, plateau phase, ca+ inflow, repolarization, k+ outflow, ca+ outflow, absolute refractory, longer than skeletal.
