MICB 202 Lecture Notes - Rna-Dependent Rna Polymerase, Dna Polymerase Iii Holoenzyme, Rna Virus
Document Summary
Rapid evolution due to: short generation time, lots of progeny, high mutation rate: mutation rate: 10^-6 to 10^-7 for viral dna pol, vs 10^-4,-5 for. Rna pol: compare to humans of 10^-11, new viruses from mutations of pre-existing strains, eg. If more than 1 capside, inner capsid=nucleocapsid: enveloped: has a phospholipid bilayer covering capsid, thru budding. Can have gps embedded to attach to host. Some have matrix proteins to link capsid with envelope. Some enveloped have core instead of capsid. Is capsid that doesn"t immediately break apart upon entering host cytoplasm. Instead, docks to nucleus before releasing genetics into nucleus: genome: linear, circular, segmented, some viruses contain own enzymes necessary for replication. If they replicate in cytoplasm can"t use dna pol from host"s nucleus or host pol not appropriate eg. retrovirus. 5 structural forms of viruses: naked, icosahedral: eg. polio, naked, helical, enveloped icosahedral: eg. hiv, enveloped, helical.
