CHEM 1004 Chapter Notes - Chapter 4: Water–Electrolyte Imbalance, Therapeutic Index, Drug Delivery

• School: Carleton University
• Department: Chemistry
• Course: CHEM 1004
• Professor: Gerald Buchanan

Document Summary

Ml and cm3 are the same (last weeks notes) death from water- 4 liters in 2 hours died from electrolyte imbalance. Therapeutic index- larger the value, safer the drug. Many accidental deaths at sick kids in 70"s due to this: marijauna-1000, alcohol- 10. Oral, inhalation, injection, body orifices, skin application, implantable drug delivery systems, microsponges. Expected to disintegrate in stomach and enter bloodstream by absorption from stomach to small intestine. Some drugs must be taken with food to avoid irritating stomach lining. Some drugs are destroyed by stomach juices and must be injected. Rapidly absorbed due to large number of blood vessels in lungs and nasal region. Slow absorption into blood stream from patch. High porosity permits large surface area to be filled with drug. Often contain active ingredient and have non-standard weights. Refer to viagra patent issue with pfizer. Some foil wrapped to keep moisture out. Contain binders to hold active ingredient together: gelatine to aid swallowing.