PSYC 475 Chapter Notes - Chapter 2: Ataxia, Biotransformation, Cytochrome P450

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Pharmacokinetics: how drugs are handled by the body. Distribution of drug throughout the body, including into a fetus. Adme determine the bioavailability of a drug how much of the drug that is administered actually reaches target. Pharmokinetics describes time course of a drug s actions (onset to duration of effect) kinetics: movement and time. 3 ranges in blood plasma: ineffective range: not enough drug present to produce effects therapeutic range toxic range. Absorption processes and mechanisms by which drugs pass from external world into the bloodstream drugs can be administered in 6 ways: Rectally: embedded in a suppository, placed in rectum. Inhaled: gases, vapours, particles in smoke or in aerosol. Absorbered through mucous membranes: insufflation snorting/ sniffing, drug depositing on the oral or nasal mucosa. ~75% of an orally admin d psychoactive drug is absorbed into the bloodstream within 1-3 hours.

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