CHEM 2OB3 Study Guide - Quiz Guide: Current Biology, Aneuploidy, Centromere
18 Jun 2014
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Minus 2. 5 marks (10%) not use of proper in-text citation* Minus 1 mark not use of ama style for in text citation and references. Provide a complete reference indicating authors, date of publication, and journal. Chiang t, duncan fe, schindler k, schultz rm, lampson ma. Current biology 2010; 20:1522-1528: why did the authors study this topic? (2 marks) It is now well established that the probability of a trisomic pregnancy (i. e. , an embryo with an extra copy of a chromosome) increases dramatically with age. Most trisomies and all autosomal monosomies are inviable, and the few that are viable result in severe developmental disabilities1. (1 mark) This observation suggested that centromere cohesion might be weakened in old oocytes1. Interkinetochore distances were measured for all sister kinetochore pairs in an oocyte and averaged over each oocyte1. (0. 25 marks) The interkinetochore distance was increased in old eggs compared to young eggs.
