BIOC 311 Lecture Notes - Lecture 6: Enzyme, Glycogen

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: all

Document Summary

Intracellular glycogen is the true substrate for anaerobic glycolysis in muscle, not blood glucose: that is breaking down glycogen into glucose is much faster than getting glucose from. Why store glycogen: need a carbohydrate store; fatty acids cannot be converted to glucose, muscle cannot mobilize and use fat as quickly as glycogen, fat cannot be metabolized anaerobically. Stores of glycogen in a 70 kg person. 30 kg of muscle @ 14g/kg 420 g. 1. 5 kg of liver @ 54g/ kg 80 g. Glycogen is accumulated under favorable conditions; stored after meals and utilized at a later time. Muscle glycogen: available for energy production for muscle contraction, muscle cannot release glucose to the blood (no glucose-6-phosphate phosphatase) Liver glycogen: used to maintain blood glucose levels between meals, glucose-6-phosphate phosphatase is present in liver. Other tissues: have small glycogen stores for their own use, energy during fasting or anaerobic glycolysis during brief periods of hypoxia/anoxia.