BIO 2133 Lecture Notes - Lecture 8: Missense Mutation, Mutation, Wild Type

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9 Jul 2014
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The most important learning outcome: understand phenotype it"s all about gene expression. , can be caused by multiple genes, or one gene, but either way, it"s still expressed. Talking about dominant and recessive alleles (these are expressed because of enzyme activity, and the threshold activity is needed for the gene to be expressed. Recessive genes" enzymatic activity is significantly lower than that of a dominant allele, and is thus a recessive condition) Midterm 1: not responsible for learning crosses & mitoises & meiosis. 1 wild-type copy enzyme activity above threshold needed for normal pigmentation, so carriers are unaffected: proteins unfold upon heating: with increasing temperature, missense mutations can destabilize 2" and 3" structures so the protein unfolds lower than normal temperature. In order to confirm what type of condition it is, we must examine the threshold energy, the amount of protein.

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