BIOL442 Lecture Notes - Lecture 5: Nuclear Pore, Rna Virus, Nuclear Transport
16 Jul 2014
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Document Summary
Some viruses require movement to nucleus for transcription. Some (like picornaviridae) carry out transcription in the cytoplasm. To get to the nucleus, interaction with cytoskeletal transport machinery (microtubules or microfilaments) is required. 2 modes; either by vesicle (endosome) movement or by freed subviral particle (partially uncoated) Uninfected neuron, transport of vesicles containing messenger molecules occurs along microtubules up to the cell body of the neuron. Infected neurons, rabies virus hitches a ride on this transport system to reach cns, including the brain. Can move 8 to 20 mm per day along axons. Time that clinical signs appear is shorter in the young and when bites are close to cns (head, neck) In cns, virus has easy access to any tissue infiltrated by neurons - including salivary glands and tear ducts. Viruses bud out from neurons in these glands into the secretions. Rabies-induced aggressive biting behavior and hyper-salivation in the host animal maximizes chance of viral infection of a new host.
