BIO 3153 Study Guide - Final Guide: G1 Phase, Protein Kinase, Dna Replication
17 Jul 2014
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Makes sure mitosis doesn"t occur at another part of the cell cycle, reduced to prevent replication at a different phase. Cdk-cyclin complexes are molecular switches and control: dna replication: g1 cell + s-phase cell = replication in g1 nucleus, chromosme segregation, cell division, cell proliferation. Regulate: dna replication, mitosis, cytokinesis: mediates phosphorylation of proteins (by transfering, resulting in activation or inactivation), dependent on cyclin, kinase phosphorylates target proteins, cyclical activity changes in cdk are controlled by cyclins (rises and falls) Cdk-cyclin complex activation triggers cell cycle events: dna replication: s-cyclin in s phase, mitosis and cytokinesis: m-cyclin in m phase. Activation of cdk-cyclin: in order to get activation of cdk, need cyclin and cdk activating kinase o. Inactive cdk (not bound with cyclin: cyclin enters (conformational change: t loop, induced by binding, phosphorylation providing by cdk act kinase, phosphate transferred from atp to cdk, by cak.
