CHEM261 Study Guide - Aspirin, Ethyl Acetate, Miscibility

• School: University of Alberta
• Department: Chemistry
• Course: CHEM261
• Professor: Hayley Wan

Document Summary

Miscibility/solubility: ability of two liquids to mix in all proportions to form homogenous solution, like dissolves like, higher density is lower layer, organic compounds can be extracted from water with hydrophobic solvents, ionic compounds and hydrophilic liquids can be separated from hydrophobic solvents by extraction with water, organic compounds can be made less soluble in water by the addition of inorganic salts. Ideal solvents for 2 solvent recrystallization: dissolve compound in minimum volume of hot solvent a, add hot solvent b, compound must dissolve in solvent a at any temperature, compound must not dissolve in solvent b at any temperature, cooling causes crystals to precipitate, solvents a and b must be miscible. Liquid solid chromatography: tlc and column, stationary phase = solid (silica, alumina)=adsorbent, mobile phase = liquid (eluent, more polar = stronger interaction with adsorbent, adsorbent usually polar, eluent mostly nonpolar.