EESA10H3 Lecture 9: TOXICOLOGY

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The science which studies toxic substances or poisons, that are substances which cause alteration or perturbation in the function of an organisms leading to harmful effects (truhaut,1974) Some times people are working with toxic substances without being aware of it. (1) Toxicology: assessing chemical hazards: how harmful a substance is (toxicity) depends on: Chemical properties of the substance, how much of the substance would be found in the water, soil, air. Chemical partition in the environment depends on: electro negativity, polarity, oxidation state, molecular weight, dissociation: cations and anions (distribution is different, solubility. Water soluble toxins: inorganic substances like heavy metals are water soluble. Fat soluble toxins (like organic toxicants like ddt) Toxicology: assessing chemical hazards (2: persistence of chemical break down environment, bioaccumulation: accumulation in some organ. Nothing to do with food chain: biomagnification: increased concentration of chemical in organism food chain, chemical interaction between 2 chemicals.

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