Pharmacology 2060A/B Study Guide - Drug Metabolism, Cyp3A4, Methyl Group

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7 Feb 2012

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Metabolism is also referred to as biotransformation. Drug metabolism evolved in humans to protect us from a number of environmental toxins as as well synthesize endogenous molecules. essential. A summary of common exogenous toxins that drug metabolism protects us from are summarized below. Similarly, endogenous essential molecules synthesized by drug metabolizing enzymes are shown. Note that even things like vegetables considered to be healthy would by toxic if we didn"t have enzymes to process them! In most clinical situations the concentration of drug is much lower than the metabolic capacity of the body. In 1st order kinetics drug metabolism is directly proportional to the concentration of free drug. This means a constant fraction of drug is metabolized per unit time. The figure in the right shows an example of 1st order metabolism. Notice how the concentration decreases faster when there are higher drug concentrations than at the end when the drug concentrations are low.

Related Questions

1-9 Match the following statements with the parameters A to I below.

1- Metabolite with different origins and several metabolic fates

2) Metabolite which is not consumed in the central metabolic pathway

3) Metabolite which is consumed in a metabolic pathway

4) Metabolic pathway with the same initial and final metabolite

5) Set of metabolic reactions which replenish the central metabolic pathway

6 Set of reactions through which the hydrogen ions and electrons are transferred from reduced cofactors to oxygen, obtaining water and releasing energy

7- Set of reaction which permit the interconversion of several metabolites, the end of the catabolism and the beginning of anabolism

8- Pathway which has both a catabolic and an anabolic role

9) The biosynthesis of ATP using the energy released in the electron transport chain

a) Central and amphibolic pathway

b) Feeding metabolite

c) Anaplerotic pathway

d) Electron transport chain

e) Anaplerotic metabolite

f) Crossroad metabolite

g) Oxidative phosphorylation

h) Amphibolic pathway

i) Metabolic cycle

18- Which of the statements below are FALSE with respect to metabolism?

a) In stage 1 of metabolism, the processes of digestion break down the large macromolecules into small monomer units by hydrolysis.

b) In stage 1 of metabolism, the hydrolysis of complex molecules that take place in the stomach during digestion converts complex molecules such as carbohydrates, proteins and fats into their component monomeric units

c) In stage 1 of metabolism, the hydrolysis of complex molecules that take place in the stomach during digestion converts complex molecules into amino acids, glucose, fructose, galactose, glycerol, and fatty acids

d) Step one in metabolism occurs at the stage of digestion of the polysaccharides, lipids, and proteins that we ingest

e) Energy generation occurs in 3 stages

f) none of the above

14. How do 5fluorodeoxyuridine monophosphate and methotrexate affect cellmetabolism? Know the specific enzymes affected and theconsequences for the cell.

15.what do adenosinedeaminase, 5

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Pharmacology 2060A/B Study Guide - Drug Metabolism, Cyp3A4, Methyl Group

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