BIO130H1 Lecture 5: Text Notes BIO130 Lecture 5 Part 1
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BIO130H1 Full Course Notes
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Introduction to dna replication short term survival of a cell depends on preventing changes in its dna long term survival of a species requires that dna be changeable through many generations. Dna maintenance process failure mutation can destroy the organism if occurring in vital position in dna sequence. Many mutations are silent i. e. change a codon, but not the amino acid it specifies, change an amino acid without affection protein activity coded for by the gene. Multicellular organisms depend on high fidelity with which dna sequences are replicated and maintained. Dna duplication must be accurate before cell division. Dna duplication rates can be as high as 1000 nucleotides per second. Dna base for base pairing aligns it for the enzyme-catalyzed polymerization into a new dna chain. Dna polymerase nucleotide-polymerizing enzyme deoxyribobuclease free nucleotides serve as substrates for dna polymerase polymerization into dna requires single strand dna template. Dna polymerase enzymes required a previously formed base paired 3"-oh.