EESA10H3 Lecture : Heavy Metals and Human Health

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Heavy metals are found in ores and extracted naturally occurring. Can be toxic in very low concentrations. Some heavy metals can bioaccumulate in liver, brain, bones. 3 classes: a, b, and c (borderline: class a. Low toxicity (but still toxic every metal is toxic depending on the concentration: class b. Very toxic form solute organometallics: class c (borderline) Examples: cr, cu, as, co, ni, zn, mn, fe. Essential for biological processes but only in small amounts trace minerals (micronutrients) Toxicity level is in between class a and class b in order of increasing toxicity: class b > Blocks essential functional groups such as proteins (enzymes) which prevents the proteins from carrying anything receptors are blocked. Class b and class c metals can displace other metals. Class b can modify the active conformation of biomolecules from active to non-active. Organisms have mechanism to stop the effects of metals. Resistance = species develop mechanisms not to uptake metals.

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