PCL201H1 Lecture 2: Lecture 2 Drug Basics

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11 Apr 2012
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Toxin: may be used as a drug adverse effects poisonous naturally formed can cause harm. Drug can be naturally produced can cause harm: may be a toxin. It can replace (agonist)/assist a natural chemical from the body. (selective. Serotonin reuptake inhibitor ssri for depression: alzheimer"s disease (increase acetylcholine, parkinson"s disease (increase dopamine, blocks the metabolism of neurotransmitters, normally neurotransmitter is released and received. Prozac blocks reuptake of neurotransmitter, increasing the amount of neurotransmitter in synaptic cleft, prolonging activity. It can be a novel compound that acts on a site in the body to activate or inhibit something (non-steroidal anti-inflammatory agent nsaid: nsaid blocks enzymes that form prostaglandins in cycloxygenase pathway. It can change or block/inhibit formation of compound/chemical in body: ace inhibitor inhibits ace (angiotensin converting enzyme), decreasing blood pressure, decreasing na+ reabsorption. It can block an endogenous compound from working (antagonist: atropine sulfate to dilate pupils. Antagonist that blocks ach (endogenous) from binding to its receptor.

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