HMB265H1 Lecture : Notes taken during lecture

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redtermite204

15 Mar 2011

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announcements: solutions manual hard copy not yet available get it in the next couple of weeks, midterm makeup done will soon post instructions to obtain copy of original exam. Started with mendelian genetics, single-gene traits then quantitative traits, mapping qtl. Now molecular aspects of genetics today: mutations. process by which allele changes into another allele. can mutate randomly, at any time, in any cell of organism. germline cell mutations are transmitted to progeny, not somatic mutations. Rate of forward mutation always higher than rate of reverse mutation. Inversion: deleted, twisted around, reinserts = 180 rotation: within same chromosomal location. classified into two different types transition, transversion. Transition purine base changed into another purine; or pyrimidine into other pyrimindine: same chemical category. Transversion purine changes into pyrimidine; vice versa. when one base changes on one strand, complementary change on opposite strand during replication. disrupt gene function so can study wildtype function of gene www. notesolution. com.

Related Questions

9.3a. Define mutation and explain the two types of mutations in multicellular organisms and their phenotypic effects.

9.3b. Define a point mutation and how it may or may not result in a new phenotype.

9.3c. Describe chromosomal mutations, including deletions, duplications, inversions, and translocations.

9.3d. Define and distinguish spontaneous and induced mutations.

9.3e. Define âhotspotâ mutation and provide two examples.

azureswan150

1. An occurrence of a gene made larger by trinucleotide repeats is:

Allelic expansion

Nucleotide expansion

Translocation mutation

Transformation

2. a chemical that can damage and/or change DNA is called a/an:

Allele

Endonuclease

Vector

Mutagen

3. An occurrence when a section of a chromosome relocates itself to an entirely different (non-homologous) chromosome is called a/an:

Inversion mutation

Translocation mutation

Transformation mutation

Duplication mutation

4. The tandem repeat in the sequence GGGAAGGGAAGGGAAGGGAAGGGAAG is:

GGA

GGGAA

GGAAG

GGAAGGG

A disease characterized by abnormally shaped hemoglobin is called:

Cystic Fibrosis

Sickle Cell Anemia

Marfan Syndrome

Leukemia

5. A point mutation that causes a substitution of a stop codon with an amino acid and leads to the formation of a longer protein is a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

6. Addition or deletion of nucleotides in a DNA sequence is known as a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

7. The least severe type of chromosomal mutation is:

Point

Frameshift

Inversion

Translocation

8. Chemicals inserting themselves into DNA can cause a:

Missense mutation

Nonsense mutation

Sense mutation

Frameshift mutation

9. A genetic condition caused by allelic expansion is:

Familial hypercholesterolemia

Fragile X syndrome

Alkaptonuria

Galactosemia

10. Which of the following is most likely the original DNA strand if the mutated DNA strand is ATAGUUGATGUA ?

ATAGAAGATGAA

ATAGCCGATGCA

ATAGGGGATGGA

ATAGTTGATGTA

11. An unbalanced chromosomal mutation would include a/an:

duplication (insertion)

inversion

translocation

denaturation

12. Many translocation mutations are found to be involved with:

cancers

sickle cell anemia

Huntington disease

cystic fibrosis

13. A common repeat throughout the human genome that is approximately 300 bases in length is called a/an:

EcoRI repeat

Hind repeat

Exo repeat

Alu repeat

14. A balanced chromosomal mutation includes:

imprintation

denaturation

inversion

deletion

salmondinosaur263

EFFECT ON SEQUENCE OR GENE of DELETION mutation

EFFECT ON SEQUENCE OR GENE of REGULATOR MUTATIONS

EFFECT ON SEQUENCE OR GENE of INSERTION mutation

What is the difference between spontaneous and induced mutationsand their effects

chocolatearmadillo30

HMB265H1 Lecture : Notes taken during lecture

HMB265H1 Full Course Notes

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