MIMM 413 Lecture : feb 13 2012- dr. shio.docx
15 May 2012
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We will discuss complications we can observe with malaria. With infection, you have increase of pro-inflammatory cytokines which can increase expression of cox-2 and arachidonic acid, which is metabolized by either of the two things underneath on the image. Nos2 is inducible nos, and increases production of no. The classical way of what happens in cerebral malaria. The rbc stick and you have interaction of infected rbc with non-infected rbc. Because you have these rbc rosettes, you can have blockage of the vessels. When you have rbc infection with p. falciparum, you have formation of the knobs. When you have the protein, you have the formation of the maurer"s clefts. (look up. Knobs are formed by secreted proteins from the parasite. With each generation of plasmodium, you have a different variation of the emp1 part. See slide (different receptors listed depending on location). Results slide: as the days go by, you have lower complement.
