CSB327H1 Lecture Notes - Lecture 4: Capsule Of Lens, Retina, Haploinsufficiency
10 Oct 2012
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Document Summary
Shaping of extracellular matrix by cells: cells exert tractional (pulling) forces on adhesive ecm molecules. Major class of cell-matrix transmembrane receptors that binds to ecm molecules such as collagen. Type i collagen can be recognized by a variety of different integrins. 1 is the common subunit in collagen receptors. Heterodimer derived from a combination of 18 subunits and 8 subunits. Vectorial discharge by fibripositor: fibril deposition into extracellular space, movement of vacuoles to the cell surface for discharge results in their preferred localization to one region of the cell. Extracellular compartments: the interface between the cell surface and the matrix, first compartment long narrow channel (fibril) Elongated vacuoles fuse into long narrow fibril-forming compartments. Extend deep into the cell: second compartment fibril forming compartment (fibril bundles) Retraction or lateral fusion of the plasma membranes of the first compartment. Manipulation of individual fibril segments is effected by interactions of the cell surface, traction and pulling forces.
