anaanie94

anaanie94

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Abortion keeps being a controversy because both sides of the spectrum have valid points. The side that is prolife it right about abortion being the termination of an organism. Their believe system states that murdering human being is wrong and since an unborn child is still a human child, then by default this should be condemned as a wrong thing. They also say they are helping the woman themselves because abortion can have “the risk of breast cancer in those who had experienced an induced abortion was 50% higher than among other women” however the same study states “the results across all epidemiologic studies of this premise are inconsistent—both overall and within specific subgroups. The risk of breast cancer should be re-examined”. This means we should not jump in to conclusion because more studies need to be done before accepting something as fact. The side for pro-choice states that a woman should have the choice to make her own decision no matter if it is a good or bad decision. A decision that will change her live completely and most of the time make it harder for a woman to get ahead in life.

I am pro-choice, not because I like terminating live, I am actually pro-live of any type of organisms not just humans, but because woman who phase this problem should have their reason or really are not prepare to have a baby in a modern society, and as Mack T Brown said “The value of a self-represented future resides within the person herself, as a feature of a richly complex mental life". Both sides of the argument go to the extreme to explain their case pro-choice and give the example of a raped woman. Pro-live give the example of that a baby is always a good thing. Both acceptable, however most woman are not in this spectrums, an example that is more relevant is a woman who does not have the emotionally and or financial maturity to make the choice that is to have a child. Physically a girl is ready to have a child when her menstrual cycle begins that is usually around 13. Most people would agree that a girl of that age will not have any type of maturity to take care of even herself less a child. Let’s not go far let’s say a girl of eighteen years old getting out of high school, she may have a rare emotional maturity at that age to have the child but in today’s society impossible without any help from family members to take care of that child. How many hours will she work? How will she take care of the child? How will she go to school to better herself for the future to come? These girls that are asking themselves if they should have an abortion is not because it is something they would like to do, it is a hard decision to postpone taking that live changing decision before they are ready to do it and not be a burden in society.

The current abortion law is strict, so abuse of the law will be very hard to do. In the third trimester a woman would need 2 signatures of two physicians to be able to do an abortion. I personally think that this is great this way we can assure that there is no negligence from any party. The part of the law I do not agree with is that the law says that if during the abortion the baby is born alive they need to offer emergency services. This defeats the purpose of an abortion that as harsh as it sounds it is to terminate the pregnancy cycle before time.

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36. A Clinical psychologist tests whether changing to a more nutritious diet will influence happiness levels. What is the research hypothesis?

a.    The change in diet will have no impact on happiness levels

b.    The change in diet will improve happiness levels

c.     The change in diet will decrease happiness levels

d.    The change in diet will change happiness levels

 

37. In statistics, the symbol μM is the:

a.    The sample mean

b.    The population mean

c.     The mean of the distribution of sample means

d.    The population standard deviation

 

38. The "cut-off sample score on the comparison distribution" is the point at which:

a.    The research hypothesis is rejected

b.    if the research hypothesis is true, a result this extreme is unlikely. 

c.     if the null hypothesis is true, a result this extreme is unlikely. 

d.    the null hypothesis is accepted.

 

39. The mean of a distribution of means is:

a.    the square-root of the original population mean. 

b.    the original population mean divided by the sample size (N). 

c.     the same as the original population mean. 

d.    the sample mean multiplied by the variance. 

 

40. A Psychologist is using a t-test to examine if taking a stress reduction course would increase how much people sleep. For this study, the significance level is .01 and the sample size is 15. What is the cut-off t-value for this study?

a.    2.625

b.    1.64

c.     2.947

d.    1.762

 

41. Which significance level(s) do Psychologists often use?

a.    .01

b.    .10

c.     .05

d.    Both A and C

 

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Merck Vioxx

In the late 90’s a leading pharmaceutical manufacturer Merck had been working on a treatment for osteoarthritis, rheumatoid arthritis and other conditions associated with pain (Prakash S, Velentine V. 2007). Merck’s solution to this health issue came in the form of Vioxx, showing promising therapeutic effects with minimal and reduced side effects associated with competitors (Union of Concerned Scientists, 2017). 1998 saw the submission by Merck for approval by the FDA for vioxx after being tested on 5400 subjects in 8 separate studies (Prakash S, Velentine V. 2007). Come 1999 another study was conducted in order to compare the drug to a popular competitor known as naproxen in which, 8000 participants were observed (Prakash S, Velentine V. 2007). Half of the participants took vioxx and the other naproxen (Prakash S, Velentine V. 2007). By the end of the year the results of the study were compiled among the Vioxx Gastrointestinal Outcomes Research study AKA Vigor where vioxx showed far fewer ulcers and intestinal bleeding than those taking naproxen (Prakash S, Velentine V. 2007). A second meeting however was focused on heart problems where 79 patients of the 4000 taking vioxx were found to have a serious event compare too 41 of 4000 taking naproxen (Prakash S, Velentine V. 2007). These figures were deemed as comparatively small and to be re-evaluated in 30 days (Prakash S, Velentine V. 2007). VIGOR re convened and were notified that vioxx patients were twice as likely to have serious heart problems and or death than those of naproxen (Prakash S, Velentine V. 2007). A vote was successfully held to continue the study under the defense of not knowing if vioxx caused the heart problems or if the patients taking naproxen was acting as a low dose aspririn and protecting patients from them (Prakash S, Velentine V. 2007).

Many pharmaceutical studies are conducted using a placebo in their control group whereas here Merck decided to use naproxen. The reason placebos are commonplace is so to have an understanding of what the effects a drug can have on an individual that isn’t taking the drug at all in order to deem its safety and effectiveness (National Institute on Aging. 2020). The comparative nature of the study was seen as a means of skewing data to push the drug through FDA approval (Union of Concerned Scientists, 2017). Scientists were seen as highlighting the benefits of naproxen making it appear as though Vioxx was safer than the results suggested (Union of Concerned Scientists, 2017). Weinblatt, a safety chair as part of the advisory committee had initially pushed for information in 2000 on cardiovascular risks but ultimately succumbed to waiting on the results to be combined with all other studies (Union of Concerned Scientists, 2017). Another form of data manipulations was found when the first draft of 16 out 20 reports listed an employee as the author but upon final draft the author had changed to an external academic drawing questions of a ghost writer (Union of Concerned Scientists, 2017). Furthermore evidence of three heart attacks were removed from records of patients taking vioxx, thousands of deaths and 100,000 heart attacks due to its approval in 1999 to its recall in 2004 (Union of Concerned Scientists, 2017). Patients who have stopped taking vioxx are still facing complications related it its use (Union of Concerned Scientists, 2017)

An estimated 20 million Americans are thought to have taken the drug and the company began facing 13000 lawsuits on behalf of 23,000 plaintiffs (Union of Concerned Scientists, 2017). Trials persisted for years to which Merck defends the study and withholding information on grounds of certain instance reporting falling outside the timeline required by the studies reporting guidelines(Union of Concerned Scientists, 2017). Of the 7 trials held Merck won 3 and came to a settlement in 2007 noted as the largest drug settlement of its time  seeing Merck pay $4.85 Billion into a settlement account and allowing them to avoid personal injury lawsuits of approximately 47,000 plaintiffs and 265 class action lawsuits (Union of Concerned Scientists, 2017).

  1. How much fault would you place on the scientists conducting the study vs the company itself and do you think they should bare any of the repercussions?
  2. Do you think including a placebo in this study either as a replacement to naproxen or in addition to it would have prevented this from happening?
  3. Weinblatt the safety chair, agreed to wait for all results to be compiled before reviewing the cardiovascular study specifically. A few months later filled out a financial disclosure statement stating he and his wife had purchase $72,985 of Merck stock. Do you think this is indicative of anything fishy?

References:

Merck Manipulated the Science about the Drug Vioxx. 2017 Oct 12. Union of Concerned Scientists. 

Prakash S, Valentine V. 2007 Nov 10. Timeline: The Rise and Fall of Vioxx. NPRorg. 

National Institute on Aging. 2020. Placebos in Clinical Trials. National Institute on Aging. 

 

 

Answer: It is difficult to determine the exact amount of fault that can be pla...

Read the story and answer the following questions:

Meningitis is a condition in which protective membranes covering parts of the nervous system become inflamed (CDC, 2022). A meningitis epidemic hit the continent of Africa in 1996 and Pfizer tested an antibiotic called Trova by comparing it to the best available treatment which was Ceftriaxone (Smith, 2011).  The testing was done in the Nigerian state of Kano (Smith, 2011).

The tests Lead to the death of 11 children and left many with brain damage, and paralysis (Smith, 2011). The documentation of the trial was brought into question (Smith, 2011).  A lawsuit was filed in which plaintiffs claimed that Pfizer failed to tell the families that an approved treatment existed and that, Pfizer had intentionally provided a low dose of the control drug (lenzer, 2006). The decision to provide a lower dose shows a lack of risk-based analysis. The New York court did not listen to the case because it was not in its jurisdiction to hear the case (Lenzer, 2006).

A Pfizer spokesperson claimed that the doses given were more than the WHO-recommended dose (Lenzer, 2006). Pfizer also claimed that the studies were done within the boundaries of Nigerian law, and that verbal consent had been taken after conveying to the parents what was happening (Lenzer, 2006).

Pfizer settled out of court and paid the Kano state government 75 million dollars and created a 35 million dollar fund to help those who were affected (Smith, 2011). A US diplomatic channel leak indicated that Pfizer had been paying investigators to find material to blackmail the Nigerian attorney general to drop the charges (Smith, 2011). FDA never approved the use of trova to treat meningitis (Lenzer, 2006). Trova was later shown to cause liver damage in adults (Lenzer, 2006).

Pfizer never published the study (Lenzer, 2006). All this goes on to show that quality control was not on point and Pfizer was not at all transparent about the study. Pfizer destroyed many lives and their lack of care has instilled vaccine hesitancy in the people of Kano, which has the potential to take many more lives (Garba and Paquette, 2021).

1- Do you believe that Pfizer should have faced harsher repercussions due to their negligence?

2- Do you believe that companies should be forced by law to publish all studies they took part in/ funded?

3- Did the claims made by Pfizer indicate that established protocols for choosing who to test on were in place?

Sources:

CDC. Meningitis. 2022, March 30th. [accessed 9th April, 2022]. [whole page]. 

Garba I, Paquette D. 2021, March 20. In this Nigerian city, Pfizer fears loom over the vaccine rollout. The Washington post. [accessed 9th April, 2023].

Lenzer J. Secret report surfaces showing that Pfizer was at fault in Nigerian drug tests. BMJ. [accessed 9th April, 2023]; 332(7552). 1233.

Answer: The decision on whether Pfizer should have faced harsher repercussions...

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