kheriand10

Part II: Human genetics
Imagine that you are a geneticist at a hospital and you are given a file for a patient
whose family has a history of cancer.
The patient, John Doe, is 18 years old and has had a biopsy done on a tumorous
growth in his adrenal gland. He has a sister, Jane, and a brother, Bob, who are younger
than he is and who are both healthy. His mother, Betty, has a diagnosis of breast
cancer. John’s father, Joe, and John’s paternal grandparents have no history of cancer.
Betty is one of four children. Her brother, Tom, and sister, Lucy, have never had cancer
or signs of cancer. Both Tom and Lucy are older than Betty. Betty had another brother,
Jake, who died very young of leukaemia. Tom has monozygotic twin daughters who are
healthy. Betty’s father, Don, died of soft tissue sarcoma in his thirties. Betty’s mother is
alive and healthy. Betty’s paternal grandmother, Don’s mother, died of a brain tumor in
her thirties. Don had no siblings.

1. (4) Given the family history, you decide to draw a pedigree to help you determine if
the cancer is caused by a heritable genetic defect. In your tree be sure to indicate
John as the propositus and follow other conventions used when making a tree.
2. (1) What is the most likely mode of inheritance of the genetic defect?
As part of your research, you also consult the OMIM (Online Mendelian Inheritance in
Man) database and come up with a short list of candidate genes could mutate to
cause John’s tumor.
MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1
OMIM #13110
• Associated with tumors of the endocrine (hormone producing) glands. Originally
known as Wermer syndrome.
• Most common tumors involve parathyroid gland, islet cells of the pancreas, and
pituitary gland.
• Other endocrine tumors include adrenal cortical tumors, carcinoid tumors and rare
pheochromocytomas, as well as tumors in other parts of the digestive tract.
LYNCH SYNDROME I
OMIM #120435
• Also known as hereditary non-polyposis colorectal cancer (HNPCC).
• Significantly increased risk of developing colorectal cancer.
• Increased risk of developing other types of cancers, such as endometrial
(uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate,
urinary tract, liver, kidney, and bile duct cancers.
LI-FRAUMENI SYNDROME; LFS
OMIM #151623
• Most common types of cancer osteosarcoma (bone cancer), soft-tissue sarcoma,
acute leukemia, breast cancer, brain cancer, and adrenal cortical tumors, which is an
organ on the top of the kidney.
• Increased risk for melanoma, Wilms' tumor, and cancers of the stomach, colon,
pancreas, esophagus, lung, and gonadal germ cells (sex organs) have also been
reported.
CARNEY COMPLEX, TYPE 1; CNC1
OMIM #160980
• Associated with spotty skin pigmentation; myxomas, which are benign
(noncancerous) connective tissue tumors. Tumors can be benign or cancerous.
• Symptoms develop when a person is in his or her early 20s.
• Other common features are Cushing’s syndrome and multiple thyroid nodules
(tumors). Features a combination of weight gain, high blood pressure, diabetes, and
easy bruising, caused by the overproduction of the hormone cortisol.
NEUROBLASTOMA, SUSCEPTIBILITY TO
OMIM #256700
• Solid cancerous tumor that begins in the nerve cells outside the brain of infants and
young children. It can start in the nerve tissue near the spine in the neck, chest,
abdomen, or pelvis, but it most often begins in the adrenal glands.
• Develops most often in infants and children younger than 5.
VON HIPPEL-LINDAU SYNDROME; VHL
OMIM #193300
• Associated with tumors arising in multiple organs. Include hemangioblastomas,
spinal cord, and eye.
• Increased risk of developing clear cell renal cell carcinoma, pheochromocytoma, and
pancreatic neuroendocrine tumor.
• Other features - kidney cysts, pancreatic cysts, epididymal cystadenomas, and
endolymphatic sac tumors.
3. (2) What disorder would you suspect John has based on the information you have
collected? Explain.
4. (1) Based on information from the OMIM database, what gene(s) is most often
associated with this disorder?
5. (2) Should you be concerned about John’s siblings developing cancer? Explain
6. (3) To confirm that John has a mutation in the suspected gene(s), what molecular
technique will you use? What tissue would you use for this test and why?

Can you answer question part 5 and 6?

* I posted this question again since the picture of the question is not showing up :https://www.chegg.com/homework-help/questions-and-answers/part-ii-human-genetics-imagine-geneticist-hospital-given-file-patient-whose-family-history-q27904022

Imagine that you are a geneticist at a hospital and you are given a file for a patient whose family has a history of cancer. The patient, John Doe, is 18 years old and has had a biopsy done on a tumorous growth in his adrenal gland. He has a sister, Jane, and a brother, Bob, who are younger than he is and who are both healthy. His mother, Betty, has a diagnosis of breast cancer. John’s father, Joe, and John’s paternal grandparents have no history of cancer. Betty is one of four children. Her brother, Tom, and sister, Lucy, have never had cancer or signs of cancer. Both Tom and Lucy are older than Betty. Betty had another brother, Jake, who died very young of leukaemia. Tom has monozygotic twin daughters who are healthy. Betty’s father, Don, died of soft tissue sarcoma in his thirties. Betty’s mother is alive and healthy. Betty’s paternal grandmother, Don’s mother, died of a brain tumor in her thirties. Don had no siblings. As part of your research, you also consult the OMIM (Online Mendelian Inheritance in Man) database and come up with a short list of candidate genes could mutate to cause John’s tumor. MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1 OMIM #13110 • Associated with tumors of the endocrine (hormone producing) glands. Originally known as Wermer syndrome. • Most common tumors involve parathyroid gland, islet cells of the pancreas, and pituitary gland. • Other endocrine tumors include adrenal cortical tumors, carcinoid tumors and rare pheochromocytomas, as well as tumors in other parts of the digestive tract. LYNCH SYNDROME I OMIM #120435 • Also known as hereditary non-polyposis colorectal cancer (HNPCC). • Significantly increased risk of developing colorectal cancer. • Increased risk of developing other types of cancers, such as endometrial (uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate, urinary tract, liver, kidney, and bile duct cancers. LI-FRAUMENI SYNDROME; LFS OMIM #151623 • Most common types of cancer osteosarcoma (bone cancer), soft-tissue sarcoma, acute leukemia, breast cancer, brain cancer, and adrenal cortical tumors, which is an organ on the top of the kidney. • Increased risk for melanoma, Wilms' tumor, and cancers of the stomach, colon, pancreas, esophagus, lung, and gonadal germ cells (sex organs) have also been reported. CARNEY COMPLEX, TYPE 1; CNC1 OMIM #160980 • Associated with spotty skin pigmentation; myxomas, which are benign (noncancerous) connective tissue tumors. Tumors can be benign or cancerous. • Symptoms develop when a person is in his or her early 20s. • Other common features are Cushing’s syndrome and multiple thyroid nodules (tumors). Features a combination of weight gain, high blood pressure, diabetes, and easy bruising, caused by the overproduction of the hormone cortisol. NEUROBLASTOMA, SUSCEPTIBILITY TO OMIM #256700 • Solid cancerous tumor that begins in the nerve cells outside the brain of infants and young children. It can start in the nerve tissue near the spine in the neck, chest, abdomen, or pelvis, but it most often begins in the adrenal glands. • Develops most often in infants and children younger than 5. VON HIPPEL-LINDAU SYNDROME; VHL OMIM #193300 • Associated with tumors arising in multiple organs. Include hemangioblastomas, spinal cord, and eye. • Increased risk of developing clear cell renal cell carcinoma, pheochromocytoma, and pancreatic neuroendocrine tumor. • Other features - kidney cysts, pancreatic cysts, epididymal cystadenomas, and endolymphatic sac tumors

Imagine that you are a geneticist at a hospital and you are given a file for a patient
whose family has a history of cancer.
The patient, John Doe, is 18 years old and has had a biopsy done on a tumorous
growth in his adrenal gland. He has a sister, Jane, and a brother, Bob, who are younger
than he is and who are both healthy. His mother, Betty, has a diagnosis of breast
cancer. John’s father, Joe, and John’s paternal grandparents have no history of cancer.
Betty is one of four children. Her brother, Tom, and sister, Lucy, have never had cancer
or signs of cancer. Both Tom and Lucy are older than Betty. Betty had another brother,
Jake, who died very young of leukaemia. Tom has monozygotic twin daughters who are
healthy. Betty’s father, Don, died of soft tissue sarcoma in his thirties. Betty’s mother is
alive and healthy. Betty’s paternal grandmother, Don’s mother, died of a brain tumor in
her thirties. Don had no siblings.

1. (4) Given the family history, you decide to draw a pedigree to help you determine if
the cancer is caused by a heritable genetic defect. In your tree be sure to indicate
John as the propositus and follow other conventions used when making a tree.
2. (1) What is the most likely mode of inheritance of the genetic defect?
As part of your research, you also consult the OMIM (Online Mendelian Inheritance in
Man) database and come up with a short list of candidate genes could mutate to
cause John’s tumor.
MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1
OMIM #13110
• Associated with tumors of the endocrine (hormone producing) glands. Originally
known as Wermer syndrome.
• Most common tumors involve parathyroid gland, islet cells of the pancreas, and
pituitary gland.
• Other endocrine tumors include adrenal cortical tumors, carcinoid tumors and rare
pheochromocytomas, as well as tumors in other parts of the digestive tract.
LYNCH SYNDROME I
OMIM #120435
• Also known as hereditary non-polyposis colorectal cancer (HNPCC).
• Significantly increased risk of developing colorectal cancer.
• Increased risk of developing other types of cancers, such as endometrial
(uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate,
urinary tract, liver, kidney, and bile duct cancers.
LI-FRAUMENI SYNDROME; LFS
OMIM #151623
• Most common types of cancer osteosarcoma (bone cancer), soft-tissue sarcoma,
acute leukemia, breast cancer, brain cancer, and adrenal cortical tumors, which is an
organ on the top of the kidney.
• Increased risk for melanoma, Wilms' tumor, and cancers of the stomach, colon,
pancreas, esophagus, lung, and gonadal germ cells (sex organs) have also been
reported.
CARNEY COMPLEX, TYPE 1; CNC1
OMIM #160980
• Associated with spotty skin pigmentation; myxomas, which are benign
(noncancerous) connective tissue tumors. Tumors can be benign or cancerous.
• Symptoms develop when a person is in his or her early 20s.
• Other common features are Cushing’s syndrome and multiple thyroid nodules
(tumors). Features a combination of weight gain, high blood pressure, diabetes, and
easy bruising, caused by the overproduction of the hormone cortisol.
NEUROBLASTOMA, SUSCEPTIBILITY TO
OMIM #256700
• Solid cancerous tumor that begins in the nerve cells outside the brain of infants and
young children. It can start in the nerve tissue near the spine in the neck, chest,
abdomen, or pelvis, but it most often begins in the adrenal glands.
• Develops most often in infants and children younger than 5.
VON HIPPEL-LINDAU SYNDROME; VHL
OMIM #193300
• Associated with tumors arising in multiple organs. Include hemangioblastomas,
spinal cord, and eye.
• Increased risk of developing clear cell renal cell carcinoma, pheochromocytoma, and
pancreatic neuroendocrine tumor.
• Other features - kidney cysts, pancreatic cysts, epididymal cystadenomas, and
endolymphatic sac tumors.
3. (2) What disorder would you suspect John has based on the information you have
collected? Explain.
4. (1) Based on information from the OMIM database, what gene(s) is most often
associated with this disorder?
5. (2) Should you be concerned about John’s siblings developing cancer? Explain
6. (3) To confirm that John has a mutation in the suspected gene(s), what molecular
technique will you use? What tissue would you use for this test and why?
7. (3) If it turns out that there is a mutation in the suspected gene(s), how can you
experimentally determine that the mutation is located in protein-coding region of the
gene(s)?

Can you answer question 3 and 4?

Imagine that you are a geneticist at a hospital and you are given a file for a patient
whose family has a history of cancer.
The patient, John Doe, is 18 years old and has had a biopsy done on a tumorous
growth in his adrenal gland. He has a sister, Jane, and a brother, Bob, who are younger
than he is and who are both healthy. His mother, Betty, has a diagnosis of breast
cancer. John’s father, Joe, and John’s paternal grandparents have no history of cancer.

Betty is one of four children. Her brother, Tom, and sister, Lucy, have never had cancer
or signs of cancer. Both Tom and Lucy are older than Betty. Betty had another brother,
Jake, who died very young of leukaemia. Tom has monozygotic twin daughters who are
healthy. Betty’s father, Don, died of soft tissue sarcoma in his thirties. Betty’s mother is
alive and healthy. Betty’s paternal grandmother, Don’s mother, died of a brain tumor in
her thirties. Don had no siblings.

As part of your research, you also consult the OMIM (Online Mendelian Inheritance in
Man) database and come up with a short list of candidate genes could mutate to
cause John’s tumor.

MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1
OMIM #13110
• Associated with tumors of the endocrine (hormone producing) glands. Originally
known as Wermer syndrome.
• Most common tumors involve parathyroid gland, islet cells of the pancreas, and
pituitary gland.
• Other endocrine tumors include adrenal cortical tumors, carcinoid tumors and rare
pheochromocytomas, as well as tumors in other parts of the digestive tract.

LYNCH SYNDROME I
OMIM #120435
• Also known as hereditary non-polyposis colorectal cancer (HNPCC).
• Significantly increased risk of developing colorectal cancer.
• Increased risk of developing other types of cancers, such as endometrial
(uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate,
urinary tract, liver, kidney, and bile duct cancers.

LI-FRAUMENI SYNDROME; LFS
OMIM #151623
• Most common types of cancer osteosarcoma (bone cancer), soft-tissue sarcoma,
acute leukemia, breast cancer, brain cancer, and adrenal cortical tumors, which is an
organ on the top of the kidney.
• Increased risk for melanoma, Wilms' tumor, and cancers of the stomach, colon,
pancreas, esophagus, lung, and gonadal germ cells (sex organs) have also been
reported.

CARNEY COMPLEX, TYPE 1; CNC1
OMIM #160980
• Associated with spotty skin pigmentation; myxomas, which are benign
(noncancerous) connective tissue tumors. Tumors can be benign or cancerous.
• Symptoms develop when a person is in his or her early 20s.
• Other common features are Cushing’s syndrome and multiple thyroid nodules
(tumors). Features a combination of weight gain, high blood pressure, diabetes, and
easy bruising, caused by the overproduction of the hormone cortisol.

NEUROBLASTOMA, SUSCEPTIBILITY TO
OMIM #256700
• Solid cancerous tumor that begins in the nerve cells outside the brain of infants and
young children. It can start in the nerve tissue near the spine in the neck, chest,
abdomen, or pelvis, but it most often begins in the adrenal glands.
• Develops most often in infants and children younger than 5.

VON HIPPEL-LINDAU SYNDROME; VHL
OMIM #193300
• Associated with tumors arising in multiple organs. Include hemangioblastomas,
spinal cord, and eye.
• Increased risk of developing clear cell renal cell carcinoma, pheochromocytoma, and
pancreatic neuroendocrine tumor.
• Other features - kidney cysts, pancreatic cysts, epididymal cystadenomas, and
endolymphatic sac tumors.

Q1) What disorder would you suspect John has based on the information you have
collected? Explain.
Q2) Based on information from the OMIM database, what gene(s) is most often
associated with this disorder?
Q3) Should you be concerned about John’s siblings developing cancer? Explain
Q4) To confirm that John has a mutation in the suspected gene(s), what molecular
technique will you use? What tissue would you use for this test and why?
Q5) If it turns out that there is a mutation in the suspected gene(s), how can you
experimentally determine that the mutation is located in protein-coding region of the
gene(s)?

What contributions will this research have in the field based on the following information ?

Lung cancer is very prominent in todays' society

Targeting cancerous tumors benefits surgical and therapeutic efforts

Current range of addressable biomarkers is satisfactory

Current methods are functional but leave much to be desired

Clinical Trials in nanoparticle and heavy metal targeting agents to come

Describe the importance of antimatter.

Sketch the solid whose volume is given by the iterated integral and rewrite the integral using the indicated order of intergration

Sorenstam Corp has an equity multiplier of 2.34 times, total assets of $4,512,895, a ROE of 17.5 percent, and a total assets turnover of 3.1 times. Calculate the firm's ROA.

c plus plus is a popular programming language introduced by john strawstrom in the year 1979. It is general purpose case sensitive language and it is called pre-compiled language. It contains both features of high level and low level language. C plus plus supports procedural programming and functional programming as well. There are different types of data type that acts as a keyword which is responsible to define a variable. The syntax of strings contains a collection of characters surrounded by double quotes for example here string is the type str is the name of the string and coffee is the value that is assigned to the string. For loop for loop is the repetition control structure that allows us to repeat a block of code for a fixed number of times instead of repeating the same code again and again. Another type of loop is while loop while loop are used in c plus are group of statements that are designed to perform a specific task. functions in c and c plus allow us to write a code inside the function and then we can use that code every time when we need it by mocking the function.

We have to use if condition because we want to find the even elements and the odd elements and for that we have to include if condition so we 'll write if array of i mod 2 that is if an element on dividing by 2 gives 0 as a remainder then it will it is even element so we'll increment the even variable this which we have written 0 will increment over here okay so in this question we have used array for loop and if else so now let 's try some other example. We will print the elements from 1 to 20 using while loop and with the help of function so first of all we 'll start with intermittent and inside int main will simply call or invoke the function by writing the name of the function print function. In order to give some space between each element while printing we have used double quotes with the space between them. Get line c in is used to take the input of a string and s is the name of the string. Now we will print another message saying that you have entered now here we'll print the string so next line and then okay now we 'll do some operations like s dot pushback this will add an element at the end of the. string. There are some more examples on each of these topics we have covered.

Hey are you avaliable for a chat? about 3210. pls

Doublewide Dealers has an ROA of 10%, a 2% profit margin, and an ROE of
15%. What is its total assets turnover? What is its equity multiplier?

11. 

60 grams of water at 70C are mixed with an equal amount of water at 30C in a completely insulated container. The final temperature of the water is 50C.

How to construct a 95% confidence interval if the sample mean is 100, the population standard deviation is 17.5 and the size of the sample is 40?

Introduction for python ?

What is the difference between biochemical, pharmaceutical, and diagnostic chemical reactions in healthcare? What is a specific example that exists for each of these chemical reaction types above and why might it be of importance to healthcare professionals? List a balanced chemical equation for each of these chemical reaction types and explain how it is used in your example above.

PLEASE NO PHOTOS

Jordan also reveals why Gatsby requested to meet with her at his party. What is the reason she gives?

A. To help him plan another party

• B. He asked her on a date

C. He wants Nick to set up a meeting for him and Daisy at Nick's house

D. He wants Nick to move out of the house

Based on what you have read about Jay Gatsby so far, how would you describe him? In chapter 4

Write 4-6 sentences including a topic sentence, evidence and explanation/ commentary.

What are ways that you can be a better communicator in your personal and professional life?

Describe how you should communicate with your supervisor, co-workers or MBSYEP staff?

List the three (3) types of chemical bonding and discuss the importance of each giving at least one example. How does chemical bonding affect your everyday life?

You will only receive credit if you answer all of the questions mentioned in paragraph format using a submission with a minimum of 250 words.

Habit helps us conserve energy as we go through our daily lives, but it also blinds us to areas we could change. Make a list of five ways you can incorporate more physical activity into your life by changing a habit, such as walking instead of riding the bus, taking the stairs in a certain building instead of the elevator, and so on. Is it realistic for you to implement some of these in your daily life? If so, do you plan to?

chemical bonding 

Assume that the amounts of weight that male college students gain during their freshman year are normally distributed with a mean of u = 1.1 kg and a standard deviation of = 5.1 kg. Complete parts (a) through (c) below.

a. If 1 male college student is randomly selected, find the probability that he gains between 0 kg and 3 kg during freshman year.

The probability is ____. Round to four decimal places as needed.

b. If 4 male college students are randomly selected, find the probability that their mean weight gain during freshman year is between 0 kg and 3 kg.

The probability is ____. (Round to four decimal places as needed.)

c. Why can the normal distribution be used in part (b) even though the sample size does not exceed 30?

◯ A. Since the original population has a normal distribution. the distribution of sample means is a normal distribution for any sample size

◯ B. Since the distribution is of sample means, not individuals, the distribution is a normal distribution for any sample size.

◯ C. Since the weight gain exceeds 30, the distribution of sample means is a normal distribution for any sample size.

◯ D. Since the distribution is of individuals, not sample means, the distribution is a normal distribution for any sample size.

In your own words, describe what it means to have high emotional intelligence, or high EQ.

True or False. Emotional intelligence is the ability to be aware of, manage and control one’s emotions. EQ considers things like self-awareness, self-regulation, motivation, empathy and social skills.

In your own words, describe how emotional intelligence in our personal and professional lives can help people to be more understanding of others, and to see things from multiple perspectives

True or False. People with high emotional intelligence utilize EQ skills to strengthen their professional relationships and pursuits.