NUR5111 Study Guide - Final Guide: Dysuria, Thiazolidinedione, Dapagliflozin

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Increases peripheral utilisation of glucose (uptake in skeletal muscle) Inhibit dpp-4, increasing concentration of incretin hormones. Glucose-dependent insulin secretion in increased & glucagon production is reduced. Agonist of receptor which regulates genes involved in lipid & glucose metabolism. Increases sensitivity of peripheral tissues to insulin. Delay gastric emptying, which slows glucose absorption & decrease appetite. Reduces glucose reabsorption in the kidney & increases its excretion in the urine. Increased risk of hypoglycaemia in renal and hepatic impairment & in elderly. Caution in conditions that may alter renal function, increase risk of tissue hypoxia, acidosis and lactic acidosis. Treatment with sulfonylurea or insulin increases risk of hypoglycaemia. Type 2 diabetes; used in combination with metformin & sulfonylureas. Contraindicated in ketoacidosis & type 1 diabetes. Treatment with sulfonylurea or insulin increase risk of hypoglycaemia.

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