BIOL1020 Study Guide - Final Guide: Metastasis, Cell Culture, Growth Factor
Cancer
Growth factors
•single molecules that speed up cell division
•Proliferation of cells happen where food and the growth factor is added to a cell culture
•With only the cell culture and food, there will be little or no growth
Density dependent inhibition
•cells stop growing when they cover the bottom of the surface
•This is because they anchor to the surface
•Having more spaces to anchor stimulates more growth
•This is called anchorage dependance
•When the surface is covered, the growth stops due to no anchorage points
•Smaller spaces cause reduced growth factors which stop cell growth
Cancer cells
•they do not receive inhibitory signals
•Scientists predict that these signals may be related to either anchorage dependance or
density depends inhibition
Cancer
•cancer is the loss of the cell cycle control
•Cancer cells either
-do not need growth factors to cycle
-Can make their own growth factors
-A mutation has happened that can make other signal molecules and receptors
Metastasis
•normal cells turn into cancer cells
•Begin tumours - grow but does not spread
•Malignant cells - spread from the original tumour
•This spreading is called metastasis
Breast cancer
•breast cancer tumours start in normal breast tissue
•They metastasis to the lymph nodes
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Document Summary
Cancer cells: they do not receive inhibitory signals, scientists predict that these signals may be related to either anchorage dependance or density depends inhibition. Cancer: cancer is the loss of the cell cycle control, cancer cells either. Do not need growth factors to cycle. A mutation has happened that can make other signal molecules and receptors. Metastasis: normal cells turn into cancer cells, begin tumours - grow but does not spread, malignant cells - spread from the original tumour, this spreading is called metastasis.
