IMED3001 Study Guide - Midterm Guide: Muscular Dystrophy, Cardiomyopathy, Enterovirus
9 Jan 2021
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Document Summary
For diagnosis and management of patients with myocardial disease and in cardiac transplant recipients. It is inserted transvenously into the right side of the heart and a small piece of septal myocardium is obtained and analysed. Hypertrophy and dilatation of all four chambers with bowing of the iv septum to the right side. Previous myocarditis (coxsackie b, enterovirus), idiopathic, toxins, connective tissue disorders, muscular dystrophies, peripartum. Can morphologically resemble end stage heart failure from other causes. Familial incidence of ~ 20% - 50% Autosomal dominant, autosomal recessive, mitochondrial inheritance, Age - between 20 50 years. Shortness of breath, easy fatigability and poor exertional capacity. Progressive cardiac dilation and systolic dysfunction. Possible mitral incompetence due to lv dilatation. Most patients pursue a downhill course and the majority die within 3 years of onset of symptoms, especially those > 55 years. Probably the end result of a variety of myocardial damage to a variety of toxic, metabolic or infectious agents.
