NURS2001 Study Guide - Final Guide: Extracellular Fluid, Leptin, Splenomegaly

• School: University of Sydney
• Department: Nursing and Midwifery
• Course: NURS2001
• Professor: Ron C

Document Summary

Pharmacokinetics what the body does to the drug (dose & concentration) Understand the physiological processes involved in the absorption, distribution and metabolism of drugs. Dosage form disintegrates and dissolves into solution, then is absorbed into the systemic circulation. Mostly occurs at the small intestine via diffusion. Only dissolved molecules in solution can interact with cellular components and cross membranes therefore factors affecting disintegration and dissolution can affect absorption. Solubility: solubility coating, extended release. Drug must be in solution to be absorbed. More soluble = better absorption = faster systemic availability. Lipid bilayer fat soluble is beneficial to cross membrane layer: charge. Ionised (charged) molecules are usually water soluble and do not readily diffuse through the cell membrane. Unionised (neutral) molecules are lipid soluble and can cross membranes: ph. Ph of the environment affects the absorption. An acidic drug is generally unionised in an acidic environment stomach.