Pharmacology 2060A/B Lecture Notes - Lecture 2: Enteric Coating, Oral Mucosa, Pharmacokinetics
9 Dec 2016
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Document Summary
Defined as the study of drug movement in the body. What the body does with the drug. Composed of four basic processes (adme) absorption, distribution, metabolism, excretion. Movement of dug from site of administration into blood. Rate of absorption depends on how quickly the drug effect will occur. Amount of drug absorption determines how intense the effect of the drug will be: rate of dissolution. Drugs must dissolve before they can be absorbed. Drugs with fast rate of dissolution will have faster onset of action than drugs with slow dissolution: surface area. Larger the surface area, faster the drug absorption. Intestine has villi which increase surface area: blood flow. Absorption is fastest in area with high blood flow maintain concentration gradient to carry blood through systemic circulation faster. Exercise increases blood flow and can increase absorption. Blood flow is decreased in heart failure, severe hypotension, hypothermia, and circulatory shock: lipid solubility.
