IMED2002 Study Guide - Final Guide: Hypochromic Anemia, Esophagogastroduodenoscopy, Coeliac Disease
30 Jun 2018
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IMED2002: Revision Notes 9
Iron:
-important mineral!
-Exists in all cells!
-Important for:!
1. RBC!
2. Myoglobin!
3. Enzyme!
4. Immune system!
How to Identify Anaemia:
-size of RBC is good indicator of cause !
-MCV used as guide for this approach!
-MCV: 80-100 fantom litres!
-RBC is microcytic if <80 = common cause: iron deficiency!!
MCV and Anaemia:
-microcytic: <80, iron deficiency!
-Microcytic: >100, folic acid and VB12 deficiency!
-When patient anaemic but MCV is normal: normocytic anaemia (80-100fL) !
-= most commonly due to haemolytic anaemia/haemolysis/renal failure!
-deficiency of iron most common cause of anaemia in Australia!
-2/3-3/4 of it in blood, the rest in muscle (myoglobin)!
Diagnosis:!
-Blood count = can tell cause of anaemia!
-Size of RBC (MCV) can be used to come up with differential diagnosis to cause of
diagnosis!
-normal is 80-100 (MCV)!
-This tells us MCV!
-FBC tells us Hb and other parameters!
-MCV most important!!
-Blood spread on blood slide, stain it, look at morphology of RBC in microscope (size,
shape and colour)!
-Assess other cells (if any abnormality)!
-If anaemic and low platelet and low WBC !
-= BM production problem (not just a problem with RBC but with all blood cells) !
-= BM stopped working!
-Can measure VB12 or folate!
Document Summary
Size of rbc is good indicator of cause. Mcv used as guide for this approach. Rbc is microcytic if <80 = common cause: iron de ciency! Microcytic: >100, folic acid and vb12 de ciency. When patient anaemic but mcv is normal: normocytic anaemia (80-100fl) = most commonly due to haemolytic anaemia/haemolysis/renal failure. De ciency of iron most common cause of anaemia in australia. 2/3-3/4 of it in blood, the rest in muscle (myoglobin) Blood count = can tell cause of anaemia. Size of rbc (mcv) can be used to come up with di erential diagnosis to cause of diagnosis. Fbc tells us hb and other parameters. Blood spread on blood slide, stain it, look at morphology of rbc in microscope (size, shape and colour) If anaemic and low platelet and low wbc. = bm production problem (not just a problem with rbc but with all blood cells)
