NEUR 2200 Study Guide - Midterm Guide: Phosphodiester Bond, Chromosome, Centromere
8 Feb 2018
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Twin spots: patches of somatic tissue that have different genotypes (c. stern) Dna is the (cid:862)tra(cid:374)sfor(cid:373)i(cid:374)g pri(cid:374)ciple(cid:863) of cells. Conservative parental double helix remains intact, both strands of daughter helices are newly synthesized. Dispersive both strands of both daughter helices contain original and newly synthesized dna. Origin (ori) initiation begins at origin of replication. Single strand binding proteins keep the dna helix open. Dna polymerase iii catalyzes phosphodiester bond formation between adjacent nucleotides. Dna polymerase i replaces rna primer with dna sequence. Dna ligase covalently joins successive okazaki fragments together. Facultative condensed in only some cells and relaxed in other cells. Metacentric centromere in the middle of the chromosome. Acrocentric centromere near one end of the chromosome. Heteroduplex region of dna between break points. Gene conversion deviations from expected 2:2 segregation. Dmc1 breaks phosphodiester bonds of both strands of one chromatid.
