BIOL 266- Final Exam Guide - Comprehensive Notes for the exam ( 75 pages long!)

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Cytoskeleton: network of protein filaments in cytoplasm of all eukaryotic cells. Functions: structure; determines cell shape and organization, mo(cid:448)e(cid:373)e(cid:374)t of (cid:272)ell a(cid:374)d o(cid:396)ga(cid:374)elles a(cid:374)d (cid:448)esi(cid:272)les . Intermediate filaments 10nm no polarity at maturity: microtubules (largest) 8nm polarity at maturity, actin filaments (smallest) 25nm polarity at maturity. These protein filaments are held and linked to organelles and the plasma membrane by accessory proteins. Not directly involved in cell movement as opposed to microtubules and actin filaments. Main function: let cells withstand mechanical stress when cell is stretched. 4 classes: 3 in cytoplasm and 1 in the nucleus . Intermediate filaments form a network through the cytoplasm and surround the nucleus and extend outside of the cell where they are attached to the plasma membrane. Desmosome: cell structure that indirectly connect intermediate filaments between cells. Intermediate filaments form the nuclear lamina: support nuclear membrane, provides attachment site for the chromatin. Meshwork structure as opposed to a rope like structure in cytoplasm.

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