ANAT 365 Final: Anat 365 review

• School: McGill University
• Department: Anatomy and Cell Biology
• Course: ANAT 365
• Professor: Heidi Mc Bride

Document Summary

Binds pi(4)p: ap2: pm to early endosome. N-terminus have gtp binding and hydrolysis domain to mediate fission: c-terminus have prd that binds to sh3 at the c-terminus of ampiphysin, a mechano-chemical enzyme. Lecture 6: when pip2+cargo reach sufficient level mu2 subunit binds to cytoplasmic tail of cargo/receptor + pip2 binds to mu/alpha. This causes conformational change of the ap2 complex and liberates llnld, which binds clathrin and drive its assembly. Lecture 7: nem: reducing agent that block atpase function, nsf: atpase, snaps: soluble cytosolic protein. In presence of high atp and high a. a, rheb atpase is in gtp bound form and activates/recruits torc on lysosome membrane. Gf also turn off tsc1/2: rheb-gtp activates effector to increase pa on lysosome surface to increase torc activity, the ragulator, senses amino acids and sits on the lysosome, will acts as a gef for switch ragb to.