IMED 401 Study Guide - Final Guide: Anakinra, Antibiotics, Organ Transplantation

• School: McGill University
• Department: Internal Medicine
• Course: IMED 401
• Professor: Ann Wechsler

Document Summary

In rapidly proliferating cells, it has no time to repair and cannot replicate. Induces death of certain t cells (an can thus induce immunosuppression in high dose) Inactivation of the agent (with electron donors, for example) Targets rapidly proliferating cells = git, gonads, hematopoietic cells. Without folic acid, thymidine (nucleoside) cannot be synthetized nor can dna. Also inhibits thymidylate synthase = blocks synthesis of thymidine. Inhibits thymidylate synthase = blocks synthesis of thymidine = cannot synthesize dna = cell death. Inhibits conversion of imp to amp and gmp. Inhibits dna polymerase = produces strand breaks and induces apoptosis. Bind tubulin, terminate assembly, causes depolymerisation of microtubules and mitotic arrest. Inhibits topoisomerase ii: impairs dna replication by causing dna strand breaks. Generates free radicals, and binds to cell membrane to alter ion transport. Binds to dna and irons and forms free radicals, leading to dna strand breaks and chromosomal.