MIMM 314 Study Guide - Complement Component 1R, Homeostasis, Pus

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2-18 surface bound c3 convertase deposits large numbers of c3b fragments on pathogen surfaces and generates c5 convertase activity. The formation of c3 convedrtases is the point where all three pathways converge: c4b2a and c3bbb both cleave c3 into c3a and c3b. C3 is the most abundant complement protein in plasma and it allows upto 1000 molecules of c3b to attach onto the surface of pathogens; thus the main effect of the complement system is to deposit large amounts of. C3b on the surface of the infection pathogen where it forms a covalently bonded coat that can signal the ultimate destruction of the pathogen by phagocytes. Next step in the complement cascade: generation of c5 convertase. In the classical and lectin pathways, c5 convertase is formed by the binding of c3b to the. Similarly, in the alternative pathway, c5 convertase is formed by the binding of c3b to c3bbb to make c3b2bb.

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