MIMM 214 Study Guide - Winter 2018, Comprehensive Midterm Notes - Cytokine, T Cell, T Helper Cell

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MIMM 214
MIDTERM EXAM
STUDY GUIDE
Fall 2018
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Lecture 1 January 4, 2017
Formative Assessments
- Integrate knowledge and prepare for exam
- 13, 2 marks each
- Only need to do five (if you do them well)
Immunology & Society Assignment
- Information literacy, science to lay audience, scientific collaboration, nature of immunology
- 25%
- Distributed throughout the semester
- Poster or paper
- SIGN UP BY THE 20th
A properly functioning immune system
- Distinguishes between self and non self
o Will only mount a response against non self
Will mount a response against a pathogenic bacteria
Will not mount a response against a self protein
- Distinguishes between dangerous non self and safe non self
o Will only mount a response against dangerous non self
Will mount a response against a pathogenic bacteria
Will not mount a response against my dog
Will not mount a response against a commensal bacteria
What happens when this breaks down
- A dysregulated immune response
o Might respond to safe non self
o Might respond to self
Immunology is fascinating and complicated
- Involved coordinated action between many different cells, molecules, and tissues over time and
space
- Terminology and concepts
- Requires background in molecular biology
- Immunology is young and constantly evolving
- Major advances have merited numerous Nobel prizes
Learning outcomes
- Identify key molecules, cells, and tissues involved in the immune system
construct complete models of innate and adaptive immune response
- Describe the main steps in the development of the key cells in the immune system
- Describe the mechanisms involved in allergy and autoimmunity
- Identify clinical applications of immunology
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Lecture 2 January 6, 2017
WATCH VIDEO
Introducing the major players
Tissues in the immune system
- Collection of organs, tissues, cells and molecules that coordinately work to protect from
infection
- Key components
o Bone marrow
o Thymus
o Lymphatics
o Lymph nodes
- Immune cells travel in the body and occupy different tissues over time
- Immune cells derive from progenitors in the bone marrow
- Some cells further mature in the thymus (T cells)
- Immune cells congregate in lymphoid tissues
- Lymph nodes are an important site for generating immune response
- Imagine immune cells traveling throughout the body
- Primary (Central) lymphoid organs = where lymphocytes are generated
o Bone marrow
o Thymus
- Secondary (peripheral) lymphoid organs = where lymphocytes are activated
o Mucosal associated lymphoid tissues (malt)
o Spleen
o Lymph nodes
Immune Cells
Key cells
- Innate Immunity
o Macrophage
o Dendritic cell
- Adaptive Immunity
o CD4 T Cell
o CD8 T Cell
o B Cell
o Differentiated Plasma B cell
- Pluripotet heatopoietic ste cell is the cell that is the acestor of all iue cells
Cells of the immune system
- Generically known as leukocytes or white blood cells
- Originate in the bone marrow
- Two main lineages:
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Document Summary

Only need to do five (if you do them well) Information literacy, science to lay audience, scientific collaboration, nature of immunology. Distinguishes between self and non self: will only mount a response against non self, will mount a response against a pathogenic bacteria, will not mount a response against a self protein. A dysregulated immune response: might respond to safe non self, might respond to self. Involved coordinated action between many different cells, molecules, and tissues over time and space. Major advances have merited numerous nobel prizes. Identify key molecules, cells, and tissues involved in the immune system construct complete models of innate and adaptive immune response. Describe the main steps in the development of the key cells in the immune system. Describe the mechanisms involved in allergy and autoimmunity. Collection of organs, tissues, cells and molecules that coordinately work to protect from infection. Key components: bone marrow, thymus, lymphatics, lymph nodes.

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