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NUR1 420 (1)

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NUR1 420
Balbinder S.Deo

CLASSIFICATION Diuretic (thiazide sparing) EXAMPLE OF MED IN CLASSIFICATION Hydrochlorothiazide (Hydrodiuril) MODE OF ACTION Interferes with absorption of sodium ions across the distal renal tubular segment of the nephron. This enhances excretion of sodium, chloride, potassium, bicarbonates, and water which decreases cardiac output and reduces plasma and extracellular fluid volume. INDICATIONS FOR USE Adjunct in treatment of edema associated with CHF, hepatic cirrhosis, renal failure, and in the management of hypertension. AVAILABILITY Capsules, tablets, oral solution USUAL DOSAGE Hypertension: Adult: PO 12.5–100 mg/day in 1–2 divided doses Edema: Adult: PO 25–200 mg/day in 1–3 divided doses ADVERSE EFFECTS Mood changes, unusual tiredness or weakness, dizziness, light- headedness, paresthesia, irregular heartbeat, weak pulse, orthostatic hypotension, dry mouth, increased thirst, nausea, vomiting, anorexia, diarrhea, pancreatitis, jaundice, thrombocytopenia, hyperglycemia, and hypokalemia. DRUG TO DRUG INTERACTIONS Insulin may antagonize hypoglycemic effects; Cholestyramine, Colestipol decrease THIAZIDE absorption. Diazoxide intensifies hypoglycemic and hypotensive effects. Increased Potassium and Magnesium loss may
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