PHGY 209 Study Guide - Final Guide: Cd28, Multiple Myeloma, Lymph Node

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: John White

Document Summary

Deendritic cell makes its way into the lymph node and meets b and t cells: interacts with the t-cell receptor with a specific marker (first specific reaction) as well as the mhc peptide. All helper t-cells have a cd4+ marker. Mhc2 are more specific to individuals than any other cells: t-cells will only recognize foreign-ness in the context of self. How to stop immune response: b7 links to cd28 to begin response, ctla4 has a higher affinity for b7 and stops the response by replacing. Ex. cd4+ th2cell binds to b7 via cd 28 and binds to mhc class ii molecule via t-cell receptor. Sig decides the specificity of antibodies that cells in the area will make. Immunoglobulin sig is the b-cell receptor (same as t-cell receptor in t-cells. Il4, 5, 6 proliferate and expand and tighten the antibody family. What do antibodies look like: albumin (homogenous molecule) is easy to determine via gel and has the highest peak.