PHGY 209 Study Guide - Final Guide: Severe Combined Immunodeficiency, Yolk Sac, Humoral Immunity

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: John White

Document Summary

1 in 100,000 children have no ability to fight off any form of infection they have no thymus gland bone marrow is abnormal no lymphoid system very tiny spleen. Stem cells from the yolk sac and fetal liver. Small pox was a dreadful infectious disease (killed 1 of 10 people) The covering of the body (skin and mucous membranes) All the different tlrs recognize different bacterial recognition most important one is tlr4. Innate (natural, nonspecific) immunity cellular and humoral factors no memory. Innate immune response early in evolution, danger signals cellular factors phagocytic cells (neutrophils, macrophages, interdigitating dendritic cells) cells with inflammatory mediators (basophils, mast cells, eosinophils) Humoral factors acute phase reactants (e. g. c-reactive protein, complement, interleukin, etc. ) Cells with inflammatory mediators (basophils, mast cells, eosinophils) Acute phase reactants (e. g c-reactive protein, complement, interleukin, etc. ) Phagocyte and monocyte are the same cell in different places. Monocyte leaves the circulation it becomes the phagocyte.