BIOLOGY 1A03 Study Guide - Final Guide: Proteomics, Nuclear Membrane, Peptide

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

The complex proteome - theme 2 module 4. Identify who protein diversity relates to fact that one gene codes for many proteins. Examine how protein activity can be controlled based on post translational modi cations + relative location. Describe the importance of alternate protein forms. Understand how interacting proteins can lead to complex + regulated cellular responses. 5 x increase in molecular diversity from gene > mrna. 10x increase in molecular diversity from mrna > functional protein. Human proteome: represents full number of proteins that are expressed by all heredity info in. Dna: 20 - 25,000 protein encoding genes discovered from human genome project. Characteristics of eukaryotes: genetic info isolated w/ double membrane in nuclear envelope, compartmentalization > more intricate control of cellular functions. What contributes to complexity of proteome: 1) alternative splicing, 2) post - translational modi cations. Stimulus > having a meal, some cells will be sensitive stimulus (sensors)