HTHSCI 2HH3 Study Guide - Final Guide: Posaconazole, Glucan, Hepatotoxicity
27 Mar 2018
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Bind to and inactivate the enzyme that cross links the. Nam subunits of peptidoglycan preventing proper formation of bacterial cell wall. Creates a weakened wall, cell wall is unable to maintain osmotic pressure causing cell rupture. Change in outer membrane to decrease cell permeability (cid:894)(cid:272)an"t come in) Modify the penicillin binding protein structure (cid:894)(cid:272)an"t (cid:271)ind so they (cid:272)an"t work(cid:895) Create beta-lactamase that cleave functional lactic ring of drug. Thickening of cell wall to prevent penetration monomers in the cell wall and prevents formation of peptidoglycan layer. Weakens cell wall so it is no longer able to contain osmotic pressure of the cell, causing the cell to rupture. Penicillin"s: gi upset, rash, anaphylaxis, seizures, hemolytic anemia, neutropenia, and thrombocytopenia. Cephalosporins: gi upset, rash, serum sickness, and seizures (with higher generations) Red man syndrome (caused by infusing vancomycin too quickly) Penicillins: otitis media, skin infections, strep throat, respiratory tract infections, pneumonia, intra-abdominal infections. Cephalosporins: skin infections, uti, pneumonia, intra-abdominal, febrile neutropenia.
