HTHSCI 1DT3 Study Guide - Quiz Guide: Polymerization, Synaptic Plasticity, Brain-Derived Neurotrophic Factor
23 Jun 2018
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stimulates oligodendrocyte production.
Direct stimulation to myelinate by axon (NCAM, L1)
Downregulation of inhibitory molecules (Lingo, Notch)
Myelin assembly can occur distal to cell body (Sherman, Brophy 2005) –
Ribosomes and RNA present in tips of processes.
Myelination programme in Schwann cells:
Radial Sorting (forming 1:1 relationship)
Activation of Myelin Programme (withdrawal from cell cycle,
upregulation of myelin proteins e.g. Pzero)
Downregulation of immature Sch Proteins
Membrane synthesis and wrapping
Conclusion
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Mechanisms of axonal growth and guidance (Short range soluble cues etc.)
Discuss the role of growth factors in CNS development
Normal CNS pathology, Abnormal Pathology
Neuroregenerative therapies
Gender Differences in Brain Development (SRY gene)
“The brain is inherently female”. Discuss with reference to sex hormone influence on brain
development, and evidence from studies of pathological conditions.
Suggest why mechanisms inhibiting/opposing regeneration of axons in CNS haven't been removed
through evolution.
Describe the main inhibitory mechanisms that can prevent mature CNS regeneration. What are the
strengths and weaknesses of artificially encouraging axon regeneration? Give specific examples of
therapies that have been trialled or could be further developed to encourage axon regeneration.
Describe the roles of various mediators and receptors in the perception of pain and, where applicable,
consider the clinical significance of their (dys)function.
What are the differences between type 1 and type 2 muscle fibres? Explain the physiological
mechanisms involved in determining a type 1 profile, including the experimental evidence for your
answer.
Explain the molecular pathways that mediate cell death in the developing central nervous system.
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Document Summary
Direct stimulation to myelinate by axon (ncam, l1) Myelin assembly can occur distal to cell body (sherman, brophy 2005) . Ribosomes and rna present in tips of processes. Activation of myelin programme (withdrawal from cell cycle, upregulation of myelin proteins e. g. pzero) Mechanisms of axonal growth and guidance (short range soluble cues etc. ) Discuss the role of growth factors in cns development. Discuss with reference to sex hormone influence on brain development, and evidence from studies of pathological conditions. Suggest why mechanisms inhibiting/opposing regeneration of axons in cns haven"t been removed through evolution. Describe the main inhibitory mechanisms that can prevent mature cns regeneration. Give specific examples of therapies that have been trialled or could be further developed to encourage axon regeneration. Describe the roles of various mediators and receptors in the perception of pain and, where applicable, consider the clinical significance of their (dys)function.
