LIFESCI 3B03 Study Guide - Midterm Guide: Glial Cell Line-Derived Neurotrophic Factor, Glycosylphosphatidylinositol, Brain-Derived Neurotrophic Factor
19 Apr 2014
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Spines input structures of dendrites where synapses form; increases surface area; local signal processing, respond differently to different inputs: small protrusions of dendritic membrane 1 2 m length; <1 m diameter; narrow neck (attached to dendritic shaft); wide spherical head (distal end, act individually (different signal than neighbor, maturation, filopodia initiation small projection; vasp, arp2/3 complex (scaffolding, binds actin), eps8 (capping protein, filopodia elongation actin polymerizes creating shaft, spine head formation post synaptic density (psd; accumulation of signaling molecules, receptors and adhesion molecules on membrane) Classes of rtks: trk receptor family neurotrophic factors, ret receptor family neurotrophic factors; gdnf family, cytokine receptor family neurotrophic factors and cytokines, eph receptor family axon guidance, egf receptor family (erbb family) epidermal growth factor; mitogen (causes cell proliferation; stops differentiation, fgf receptor family fibroblast growth factor, vegf receptor family vascular endothelial growth factor, pdgf receptor family platelet derived growth factor, insulin receptor family insulin like growth factors.
