LIFESCI 3A03 Study Guide - Tubulin, Morphism Of Algebraic Varieties, Acute Leukemia
6 Dec 2014
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Document Summary
Normal cells divide to produce first mutation daughter cells that override cell checkpoint bypassing apoptosis, these cells divide to produce second mutation daughter cells, fourth/late mutation cells are mutated enough to grow and proliferate uncontrollably: benign tumors are not cancerous and do not spread to other parts of the body, malignant tumours are cancerous and invade nearby tissues through metastasis. Importance of tumout suppressors: p53 is a tumour suppressing transcription factor protein that halts cell cycle after dna damage, also signals cell apoptosis, mutated, non functional form is found in half of all cancer cases. mutation model. Identifying abnormalities through biopsy: proliferative lesions without atypia (1. 3 2x increased risk) lesions in the breast that are not cancerous but show active growth and division in breast tissue, ie. hyperplasia or fibroadenoma, proliferative lesions with atypia (3 6x increased risk) Less platelets: bleeding/bruising, frequent infections, loss of appetite, weight loss, bone pain.
