PSYCH 2AP3 Study Guide - Midterm Guide: Tachycardia, Agoraphobia, Comorbidity

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Very brief (15 20 mins), intense feelings parasthesias (tingling, locations of numbness); derealization/depersonalization: average age of onset late 20s, annual prevalence= 3, lifetime prevalence= 2 5, lifetime prevalence world wide= 1. 5 3, course is variable and unpredictable. Biological: 10 25% concordance rate among 1st degree relatives; 1 3% in controls may have a genetic basis (strong concordance rate does not prove this) may be due to social learning, living together for periods of time, tendency to hyperventilate associated with disorder systemic problem in managing anxiety, catecholamines reported to be high; levels of mao also high; hyperstimulation of the adrenergic system (responsible for sns activity) hyperreactivity, hypersensitivity, sodium lactate infusion 70% respond with pd symptoms (results in substantial release of norepinephrine may be associated with panic attacks, pet scans: hyperactivity of the brain individuals who respond to na lactate infusion show higher brain activity especially in the non dominant hippocampus (responsible for emotion memory formation)

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