BIOL 331 Study Guide - Final Guide: Clustal, Phylogenetic Tree, Blosum
17 Mar 2016
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Document Summary
Sequencing switch over to the algorithm side because we have enough data to work with. Database lecture: due with technical details, need to pull iles and know what they mean. Recognise primary and secondary databases (some are archives to store data forever) Secondary databases where informaion is derived from primary sequence. All stuf we have about small conserved structural domains is secondary. Amino acid scoring much more complex, due to variability. Emphasize those scoring systems are based on observing nature. Pam and blosum (how derived, how they work) Basically integral to scores you get out of any of the programs. 70 millions snps, gaps less frequent (inserions and deleions common type of mutaion) Program searches for highest scores based on ideniies, if you allow gaps to stretch, ind a lot of sequences, if you restrain stops this. Regions with highest scores are more evoluionarily conserved. Criically important to maintain 3d structure in these area.
