MICR 221 Study Guide - Final Guide: Stat1, Immunoglobulin M, Rolling Circle Replication
18 Aug 2016
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Document Summary
Why are we not always sick even though we inhale 10 000 microorganisms/day. Can"t kill the host 100% of else there will be no more host for them to use. Host can"t clear the virus completely or else there will be no reservoir for virus to persist. Polydnavirus allows egg to express worm dna so it can"t recognize it to kill it! No! the genes are integrated into the wasp genome (the virus is the wasp), all the proteins that make up the virus particle is in the wasp. 10% are human endogenous retroviruses (hervs): representative of ancient retroviral integrations (germline) Erv fusion protein (an endogenous retrovirus) that drives formation of syncytiotrophoblast. Targeted mutagenesis to break specific places and replace the dna with what you want to introduce. Unlocking old viruses! (ie. that paramecium in the siberian ice: host defenses: physical and immunological, microbial specificity: proportionally few microbes are capable of infecting, don"t have the receptors for dog viruses.
