MICR 360 Study Guide - Final Guide: Memory T Cell, Knockout Mouse, Interleukin 15

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

Memory cells survive months-years in the absence of ag. Repeated exposure can strengthen memory + maintain it for longer. Vaccines may stim ab, cd4 memory and cd8 memory like the small pox vaccine or may just stim 1 of the 3. 2ndary exposure to ag can change memory cell phenotype so they become an effector cell again. Tcm: central memory, travel thru blood to 2 lymph tissue, live longer + divide more than. Tem, rapidly reactivate by 2nd ag exposure to become effector cells but slower than tem. Tem: effector memory, travel b/n inflamed tissues, contribute better to 1st line defense + secrete large amounts of ifngamma, shift rapidly into effector cells when exposed to ag. Il-7 (dc, stromal and epithelial cells) and il-15 (macro) for survival and persistence of memory cells. Need signaling from il-7r and il-15r for survival and division. Memory divide more frequently than na ve, less dependent on ags so need less amounts of ag.