HSM 330 Study Guide - Vasoactive Intestinal Peptide, Tumor Necrosis Factor Alpha, Estrogen Receptor

• School: Ryerson University
• Department: Health Services Management
• Course: HSM 330
• Professor: Daolun Chen

Document Summary

Eskandari - neural-immune interactions in health and disease. Cns signals immune system via hormonal & neuronal pathways and immune sysem sig nals cns through similar routes via immune mediators & cytokines. Primary hormonal pathway by which cns regulates immune system is hypothalamic-p ituitary-adrenal (hpa) axis, through hormones of neuroendocrine stress response. Sympathetic ns regulates immune system function primarily via adrenergic nts re leased through neural routes. Neuroendocrine regulaltion of immune function is essential for survival during stress/infection and to modulate immune responses in inflammatory disease. Glucocorticoids are main effector endpoint of neuroendocrine response system. Numerous routes by which immune, endocrine, and cns communicate. Cns regulates immune system locally at sites of inflammation, regionally in imm une organs, and systemically through hormonal routes. Immune system regulates cns -ex: cytokines produced at an inflammatory site sig nal brain to produce symptoms of sickness-related behaviour and fever. Interruptions/perturbations of these connective pathways can alter severity, co urse, and susceptibility and resistance to diseases.