PAT 20A/B Study Guide - Midterm Guide: Brain Ischemia, Cerebral Circulation, Ischemia
14 Feb 2020
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Week 1 objectives: differentiate between cerebral hypoxia and cerebral ischemia; and between focal and global ischemia. Failure to oxygenate bld while maintaining adequate blood flow (perfusion) Could be a result from high altitudes, carbon monoxide exposure. Interferes with delivery of o2 & glucose & removal of metabolic wastes. Focal (region of brain)- most commonly manifested as focal; ie: occurring in certain area of the brain often from stroke. Overexcitementof the neurons is deadly to the cells. Calcium in the cell triggers glutamate note that calcium is building up in the cell bc. Atpase isn"t functioning and cannot remove it out of the cell more depolarization fo the cell allows for more ca in to the cell and thus more glutamate into the cell. Ischemia causes atp levels to drop ionic imbalance and neurotransmitter. _glutamate__ release na+ & h2o to invade surrounding neurons neuron depolarization & ca2+ moves into cells.
